Browsing Moksliniai ir apžvalginiai straipsniai / Research and Review Articles by Institution "Nacionalinis vėžio institutas"
Now showing items 1-20 of 35
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A refinement of clinical tumor marker monitoring: Why not use an inverse value of doubling time?
(Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2021)OBJECTIVES: The aim of this study was to compare prostate-specific antigen (PSA) kinetics - half-life time (HT), doubling time (DT), and elimination rate PSA (ePSA) in prostate cancer (PCa) monitoring. Implementation of ... -
Accumulation and Toxicity of Superparamagnetic Iron Oxide Nanoparticles in Cells and Experimental Animals
(International Journal of Molecular Sciences, 2016)The uptake and distribution of negatively charged superparamagnetic iron oxide (Fe3O4) nanoparticles (SPIONs) in mouse embryonic fibroblasts NIH3T3, and magnetic resonance imaging (MRI) signal influenced by SPIONs injected ... -
Annotation of the medical images using quick response codes
(Computer science and information systems, 2017)The article proposes a novel annotating method of sufficient capacity and intended not only on-line but for off-line using for information preservation all advantages of two-dimensional barcodes. The semantic annotations ... -
Asymptomatic primary tumour in incurable metastatic colorectal cancer: is there a role for surgical resection prior to systematic therapy or not?
(Videosurgery and other miniinvasive techniques, 2016)Introduction: The role of the resection of asymptomatic primary colorectal cancer in patients with incurable disease is questionable. Aim: To evaluate the impact of the resection of asymptomatic primary tumour on overall ... -
Biodistribution of multimodal gold nanoclusters designed for photoluminescence-SPECT/CT imaging and diagnostic
(Nanomaterials: Special issue: Noble metal nanomaterials for biomedical applications, 2022)Highly biocompatible nanostructures for multimodality imaging are critical for clinical diagnostics improvements in the future. Combining optical imaging with other techniques may lead to important advances in diagnostics. ... -
Blood plasma stabilized gold nanoclusters for personalized tumor theranostics
(Cancers, 2022)Personalized cancer theranostics has a potential to increase efficiency of early cancer diagnostics and treatment, and to reduce negative side-effects. Protein-stabilized gold nanoclusters may serve as theranostic agents. ... -
Comparative evaluation of cellular uptake of free and liposomal doxorubicin following short term exposure
(Anticancer research, 2021)Background/Aim: Liposomal Doxorubicin (lipDOX) and free Doxorubicin (DOX) are reported to exhibit similar antitumor efficacy. However, cellular internalization mechanisms of lipDOX are still a subject of controversy. ... -
Comparison of B lymphocyte effects of laparoscopic versus open prostatectomy in prostate cancer patients
(European journal of molecular & clinical medicine, 2021) -
Designing a red-emitting viscosity-sensitive BODIPY fluorophore for intracellular viscosity imaging
(Chemistry – a European journal, 2021)Viscosity imaging at a microscopic scale can provide important information about biosystems, including the development of serious illnesses. Microviscosity imaging is achievable with viscosity-sensitive fluorophores, the ... -
Development of a cardio-oncology service in Lithuania: Prediction, prevention, monitoring and treatment of cancer treatment-induced cardiotoxicity
(Journal of cardiovascular development and disease: Cardiovascular Toxicity Related to Cancer Treatment, 2022)Background: Advances in cancer therapy have dramatically improved outcomes for cancer pa-tients. However, cancer treatment can cause several cardiovascular (CV) complications, increasing cardiac mortality and morbidity in ... -
Exploring BODIPY-Based sensor for Imaging of intracellular microviscosity in human breast cancer cells
(International journal of molecular sciences, 2022)BODIPY-based molecular rotors are highly attractive imaging tools for imaging intracellular microviscosity in living cells. In our study, we investigated the ability to detect the microviscosity of biological objects by ... -
Functional antigen processing and presentation mechanism as a prerequisite factor of response to treatment with dendritic cell vaccines and anti-PD-1 in preclinical murine LLC1 and GL261 tumor models
(Cancer immunology, immunotherapy, 2022)Low efficacy of cancer immunotherapy encourages the search for possible resistance mechanisms and biomarkers that would predict the outcome of immunotherapy in oncology patients. Most cancer immunotherapies act on T ... -
Hitchhiking nanoparticles: Mesenchymal stem cell-mediated delivery of theranostic nanoparticles
(ACS applied materials and interfaces, 2021)Nanotechnology has emerged as a promising solution to permanent elimination of cancer. However, nanoparticles themselves lack specificity to tumors. Due to enhanced migration to tumors, mesenchymal stem cells (MSCs) were ... -
Imaging of the internal chorion structure of rainbow trout Oncorhynchus mykiss live embryos and the distribution of quantum dots therein: Towards a deeper understanding of potential nanotoxicity
(Science of the total environment, 2021)Quantum dots (QDs) are extensively explored in biomedicine but the understanding of the mechanism underlying the uptake of colloidal QDs by biological systems is still poor. The knowledge of their distribution in tissues ... -
Immunophenotype rearrangement in response to tumor excision may be related to the risk of biochemical recurrence in prostate cancer patients
(Journal of clinical medicine: Special Issue Recent Advances in Prostate Cancer Treatment, 2021)BACKGROUND: Prostate cancer (PCa) is known to exhibit a wide spectrum of aggressiveness and relatively high immunogenicity. The aim of this study was to examine the effect of tumor excision on immunophenotype rearrangements ... -
Impact of quantum dot surface on complex formation with chlorin e6 and photodynamic therapy
(Nanomaterials, 2019)Nanomaterials have permeated various fields of scientific research, including that of biomedicine, as alternatives for disease diagnosis and therapy. Among different structures, quantum dots (QDs) have distinctive ... -
Influence of halide ions on the structure and properties of copper indium sulphide quantum dots
(Chemical communications, 2020)In the synthesis of CuInS2 quantum dots (QDs), the halide ions present in the copper salts influence the QD growth and optical properties. X-ray absorption spectroscopy allowed rationalizing the halide incorporation in the ... -
Interaction of carboxylated CdSe/ZnS quantum dots with fish embryos: Towards understanding of nanoparticles toxicity
(Science of the total environment, 2018)Due to colloidal instability even with protective coatings, nanoparticles tend to aggregate in complex environments and possibly interact with biota. In this study, visualization of quantum dots (QDs) interaction with ... -
Isocytosine deaminase Vcz as a novel tool for the prodrug cancer therapy
(BMC Cancer, 2019)Background: The cytosine deaminase (CD)/5-fluorocytosine (5-FC) system is among the best explored enzyme/prodrug systems in the field of the suicide gene therapy. Recently, by the screening of the environmental metagenomic ... -
Low-dose ionizing radiation effects on differentiation of HL-60 cells
(Central European journal of biology, 2010)The biological effects of low-dose radiation have attracted attention, but data are currently insufficient to fully understand the beneficial role of the phenomenon. In the present study, we have investigated the effects ...