Rodyti trumpą aprašą

dc.contributor.authorDapkutė, Dominyka
dc.contributor.authorPlečkaitis, Marijus
dc.contributor.authorBulotienė, Danutė
dc.contributor.authorDaunoravičius, Dainius
dc.contributor.authorRotomskis, Ričardas
dc.contributor.authorKarabanovas, Vitalijus
dc.date.accessioned2023-09-18T16:08:00Z
dc.date.available2023-09-18T16:08:00Z
dc.date.issued2021
dc.identifier.issn1944-8244
dc.identifier.urihttps://etalpykla.vilniustech.lt/handle/123456789/111530
dc.description.abstractNanotechnology has emerged as a promising solution to permanent elimination of cancer. However, nanoparticles themselves lack specificity to tumors. Due to enhanced migration to tumors, mesenchymal stem cells (MSCs) were suggested as cell-mediated delivery vehicles of nanoparticles. In this study, we have constructed a complex composed of photoluminescent quantum dots (QDs) and a photosensitizer chlorin e6 (Ce6) to obtain multifunctional nanoparticles, combining cancer diagnostic and therapeutic properties. QDs serve as energy donors—excited QDs transfer energy to the attached Ce6 via Förster resonance energy transfer, which in turn generates reactive oxygen species. Here, the physicochemical properties of the QD-Ce6 complex and singlet oxygen generation were measured, and the stability in protein-rich media was evaluated, showing that the complex remains the most stable in protein-free medium. In vitro studies on MSC and cancer cell response to the QD-Ce6 complex revealed the complex-loaded MSCs’ potential to transport theranostic nanoparticles and induce cancer cell death. In vivo studies proved the therapeutic efficacy, as the survival of tumor-bearing mice was statistically significantly increased, while tumor progression and metastases were slowed down.eng
dc.formatPDF
dc.format.extentp. 43937-43951
dc.format.mediumtekstas / txt
dc.language.isoeng
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)
dc.relation.isreferencedbyScopus
dc.rightsNeprieinamas
dc.source.urihttps://pubs.acs.org/doi/10.1021/acsami.1c10445
dc.titleHitchhiking nanoparticles: Mesenchymal stem cell-mediated delivery of theranostic nanoparticles
dc.typeStraipsnis Web of Science DB / Article in Web of Science DB
dcterms.references58
dc.type.pubtypeS1 - Straipsnis Web of Science DB / Web of Science DB article
dc.contributor.institutionNacionalinis vėžio institutas Vilniaus universitetas
dc.contributor.institutionNacionalinis vėžio institutas
dc.contributor.institutionVilniaus universitetas
dc.contributor.institutionNacionalinis vėžio institutas Vilniaus Gedimino technikos universitetas
dc.contributor.facultyFundamentinių mokslų fakultetas / Faculty of Fundamental Sciences
dc.subject.researchfieldN 011 - Biofizika / Biophysics
dc.subject.researchfieldT 005 - Chemijos inžinerija / Chemical engineering
dc.subject.researchfieldT 008 - Medžiagų inžinerija / Material engineering
dc.subject.studydirectionD05 - Biofizika / Biophysics
dc.subject.studydirectionF05 - Biotechnologijos / Biotechnology
dc.subject.studydirectionF03 - Medžiagų technologijos / Materials technology
dc.subject.vgtuprioritizedfieldsFM0202 - Ląstelių ir jų biologiškai aktyvių komponentų tyrimai / Investigations on cells and their biologically active components
dc.subject.ltspecializationsL105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies
dc.subject.enphotodynamic therapy
dc.subject.enphotosensitizer
dc.subject.enmesenchymal stem cells
dc.subject.enquantum dots
dc.subject.encell-mediated delivery
dc.subject.enenergy transfer
dc.subject.entheranostics
dcterms.sourcetitleACS applied materials and interfaces
dc.description.issueiss. 37
dc.description.volumevol. 13
dc.publisher.nameACS publications
dc.publisher.cityWashington
dc.identifier.doi000700877100009
dc.identifier.doi10.1021/acsami.1c10445
dc.identifier.elaba104609475


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