dc.contributor.author | Novickij, Vitalij | |
dc.contributor.author | Balevičiūtė, Austėja | |
dc.contributor.author | Malyško-Ptašinskė, Veronika | |
dc.contributor.author | Želvys, Augustinas | |
dc.contributor.author | Radzevičiūtė, Eivina | |
dc.contributor.author | Kos, Bor | |
dc.contributor.author | Zinkevičienė, Auksė | |
dc.contributor.author | Miklavčič, Damijan | |
dc.contributor.author | Novickij, Jurij | |
dc.contributor.author | Girkontaitė, Irutė | |
dc.date.accessioned | 2023-09-18T16:11:00Z | |
dc.date.available | 2023-09-18T16:11:00Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0018-9294 | |
dc.identifier.other | (SCOPUS_ID)85119455225 | |
dc.identifier.uri | https://etalpykla.vilniustech.lt/handle/123456789/112168 | |
dc.description.abstract | This work focuses on bleomycin electrochemotherapy using new modality of high repetition frequency unipolar nanosecond pulses. As a tumor model, Lewis lung carcinoma (LLC1) cell line in C57BL mice (n = 42) was used. Electrochemotherapy was performed with intertumoral injection of bleomycin (50 L of 1500 IU solution) followed by nanosecond and microsecond range electrical pulse delivery via parallel plate electrodes. The 3.5 kV/cm pulses of 200 and 700 ns were delivered in a burst of 200 at frequencies of 1 kHz and 1 MHz. For comparison of treatment efficiency, a standard 1.3 kV/cm x 100 s x 8 protocol was used. It was shown that it is possible to manipulate the efficacy of unipolar sub-microsecond electrochemotherapy solely by the time delay between the pulses. Also, the results suggest that the sub-microsecond range pulses can be as effective as the protocols in European Standard Operating Procedures on Electrochemotherapy (ESOPE) using 100 s pulses. | eng |
dc.format | PDF | |
dc.format.extent | p. 1-7 | |
dc.format.medium | tekstas / txt | |
dc.language.iso | eng | |
dc.relation.isreferencedby | Scopus | |
dc.relation.isreferencedby | Science Citation Index Expanded (Web of Science) | |
dc.title | Effects of time delay between unipolar pulses in high frequency nano-electrochemotherapy | |
dc.type | Straipsnis Web of Science DB / Article in Web of Science DB | |
dcterms.references | 37 | |
dc.type.pubtype | S1 - Straipsnis Web of Science DB / Web of Science DB article | |
dc.contributor.institution | Vilniaus Gedimino technikos universitetas | |
dc.contributor.institution | Valstybinis mokslinių tyrimų institutas Inovatyvios medicinos centras | |
dc.contributor.institution | University of Ljubljana | |
dc.contributor.faculty | Elektronikos fakultetas / Faculty of Electronics | |
dc.subject.researchfield | T 001 - Elektros ir elektronikos inžinerija / Electrical and electronic engineering | |
dc.subject.researchfield | N 010 - Biologija / Biology | |
dc.subject.vgtuprioritizedfields | MC0404 - Bionika ir biomedicinos inžinerinės sistemos / Bionics and Biomedical Engineering Systems | |
dc.subject.ltspecializations | L105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies | |
dc.subject.en | electric fields | |
dc.subject.en | electrodes | |
dc.subject.en | electroporation | |
dc.subject.en | fluorescence | |
dc.subject.en | high frequency pulses | |
dc.subject.en | mice | |
dc.subject.en | protocols | |
dc.subject.en | sub-microsecond electroporation | |
dc.subject.en | in vivo | |
dc.subject.en | LLC1 | |
dc.subject.en | tumors | |
dcterms.sourcetitle | IEEE Transactions on Biomedical Engineering | |
dc.publisher.name | IEEE | |
dc.identifier.doi | 2-s2.0-85119455225 | |
dc.identifier.doi | 85119455225 | |
dc.identifier.doi | 0 | |
dc.identifier.doi | 132285035 | |
dc.identifier.doi | 000803112800022 | |
dc.identifier.doi | 10.1109/TBME.2021.3129176 | |
dc.identifier.elaba | 112625541 | |