dc.contributor.author | Liakina, Valentina | |
dc.contributor.author | Strainienė, Sandra | |
dc.contributor.author | Stundienė, Ieva | |
dc.contributor.author | Maksimaitytė, Vaidota | |
dc.contributor.author | Kazėnaitė, Edita | |
dc.date.accessioned | 2023-09-18T16:21:19Z | |
dc.date.available | 2023-09-18T16:21:19Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1948-5182 | |
dc.identifier.uri | https://etalpykla.vilniustech.lt/handle/123456789/113418 | |
dc.description.abstract | Recently, the gut microbiota has been recognized as an obvious active player in addition to liver steatosis/steatohepatitis in the pathophysiological mechanisms of the development of hepatocellular carcinoma (HCC), even in the absence of cirrhosis. Evidence from clinical and experimental studies shows the association of specific changes in the gut microbiome and the direct contribution to maintaining liver inflammation and/or cancerogenesis in nonalcoholic fatty liver disease-induced HCC. The composition of the gut microbiota differs significantly in obese and lean individuals, especially in the abundance of pro-inflammatory lipopolysaccharide-producing phyla, and, after establishing steatohepatitis, it undergoes minor changes during the progression of the disease toward advanced fibrosis. Experimental studies proved that the microbiota of obese subjects can induce steatohepatitis in normally fed mice. On the contrary, the transplantation of healthy microbiota to obese mice relieves steatosis. However, further studies are needed to confirm these findings and the mechanisms involved. In this review, we have evaluated well-documented clinical and experimental research on the role of the gut microbiota in the manifestation and promotion of HCC in nonalcoholic steatohepatitis (NASH). Furthermore, a literature review of microbiota alterations and consequences of dysbiosis for the promotion of NASH-induced HCC was performed, and the advantages and limitations of the microbiota as an early marker of the diagnosis of HCC were discussed. | eng |
dc.format | PDF | |
dc.format.extent | p. 1277-1290 | |
dc.format.medium | tekstas / txt | |
dc.language.iso | eng | |
dc.relation.isreferencedby | Emerging Sources Citation Index (Web of Science) | |
dc.relation.isreferencedby | Scopus | |
dc.rights | Laisvai prieinamas internete | |
dc.source.uri | https://talpykla.elaba.lt/elaba-fedora/objects/elaba:137267012/datastreams/MAIN/content | |
dc.title | Gut microbiota contribution to hepatocellular carcinoma manifestation in non-alcoholic steatohepatitis | |
dc.type | Straipsnis Web of Science DB / Article in Web of Science DB | |
dcterms.license | Creative Commons – Attribution – NonCommercial – 4.0 International | |
dcterms.references | 99 | |
dc.type.pubtype | S1 - Straipsnis Web of Science DB / Web of Science DB article | |
dc.contributor.institution | Vilniaus universitetas Vilniaus Gedimino technikos universitetas | |
dc.contributor.institution | Vilniaus universitetas Antakalnio poliklinika | |
dc.contributor.institution | Vilniaus universitetas | |
dc.contributor.faculty | Fundamentinių mokslų fakultetas / Faculty of Fundamental Sciences | |
dc.subject.researchfield | M 001 - Medicina / Medicine | |
dc.subject.researchfield | N 004 - Biochemija / Biochemistry | |
dc.subject.vgtuprioritizedfields | FM0202 - Ląstelių ir jų biologiškai aktyvių komponentų tyrimai / Investigations on cells and their biologically active components | |
dc.subject.ltspecializations | L105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies | |
dc.subject.en | gut microbiota | |
dc.subject.en | hepatocellular carcinoma | |
dc.subject.en | non-alcoholic steatohepatitis | |
dc.subject.en | non-alcoholic fatty liver disease | |
dc.subject.en | microbiome | |
dcterms.sourcetitle | World journal of hepatology | |
dc.description.issue | no. 7 | |
dc.description.volume | vol. 14 | |
dc.publisher.name | Baishideng Publishing Group Inc | |
dc.publisher.city | Pleasanton | |
dc.identifier.doi | 000847252800002 | |
dc.identifier.doi | 10.4254/wjh.v14.i7.1277 | |
dc.identifier.elaba | 137267012 | |