dc.contributor.author | Novickij, Vitalij | |
dc.contributor.author | Grainys, Audrius | |
dc.contributor.author | Lastauskienė, Eglė | |
dc.contributor.author | Kananavičiūtė, Rūta | |
dc.contributor.author | Pamedytytė, Dovilė | |
dc.contributor.author | Zinkevičienė, Auksė | |
dc.contributor.author | Kalėdienė, Lilija | |
dc.contributor.author | Novickij, Jurij | |
dc.contributor.author | Paškevičius, Algimantas | |
dc.contributor.author | Švedienė, Jurgita | |
dc.date.accessioned | 2023-09-18T16:24:56Z | |
dc.date.available | 2023-09-18T16:24:56Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 2314-6133 | |
dc.identifier.uri | https://etalpykla.vilniustech.lt/handle/123456789/113546 | |
dc.description.abstract | Candida lusitaniae is an opportunistic yeast pathogen, which can readily develop resistance to antifungal compounds and result in a complex long-term treatment. The efficient treatment is difficult since structure and metabolic properties of the fungal cells are similar to those of eukaryotic host. One of the potential methods to improve the inhibition rate or the cell permeability to inhibitors is the application of electroporation. In this work we investigated the dynamics of the growth inhibition and membrane permeabilization of C. lusitaniae by utilizing the various pulse shape and duration electric field pulses. Our results indicated that single electroporation procedure using 8 kV/cm electric field may result in up to 51 ± 5% inhibition rate. Also it has been experimentally shown that the electroporation pulse shapemay influence the inhibitory effect; however, the amplitude of the electric field and the pulse energy remain the most important parameters for definition of the treatment outcome. The dynamics of the cell membrane permeabilization in the 2–8 kV/cm electric field were overviewed. | eng |
dc.format | PDF | |
dc.format.extent | Art. No. 457896 | |
dc.format.medium | tekstas / txt | |
dc.language.iso | eng | |
dc.relation.isreferencedby | Academic Search Complete | |
dc.relation.isreferencedby | Scopus | |
dc.relation.isreferencedby | Science Citation Index Expanded (Web of Science) | |
dc.relation.isreferencedby | Biological Abstracts | |
dc.rights | Laisvai prieinamas internete | |
dc.source.uri | http://www.hindawi.com/journals/bmri/2015/457896/ | |
dc.source.uri | https://talpykla.elaba.lt/elaba-fedora/objects/elaba:13966957/datastreams/MAIN/content | |
dc.subject | MC02 - Elektros ir elektroniniai įrenginiai bei sistemos / Electrical and electronic devices and systems | |
dc.title | Growth inhibition and membrane permeabilization of Candida lusitaniae using varied pulse shape electroporation | |
dc.type | Straipsnis Web of Science DB / Article in Web of Science DB | |
dcterms.accessRights | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
dcterms.references | 30 | |
dc.type.pubtype | S1 - Straipsnis Web of Science DB / Web of Science DB article | |
dc.contributor.institution | Vilniaus Gedimino technikos universitetas | |
dc.contributor.institution | Vilniaus universitetas | |
dc.contributor.institution | Valstybinis mokslinių tyrimų institutas Inovatyvios medicinos centras | |
dc.contributor.institution | Gamtos tyrimų centras | |
dc.contributor.faculty | Elektronikos fakultetas / Faculty of Electronics | |
dc.subject.researchfield | N 010 - Biologija / Biology | |
dc.subject.researchfield | N 011 - Biofizika / Biophysics | |
dc.subject.researchfield | T 001 - Elektros ir elektronikos inžinerija / Electrical and electronic engineering | |
dc.subject.ltspecializations | L105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies | |
dc.subject.en | candida lusitaniae | |
dc.subject.en | electroporation | |
dc.subject.en | membrane permeabilisation | |
dcterms.sourcetitle | BioMed Research International | |
dc.description.volume | Vol. 2015 | |
dc.publisher.name | Hindawi Publishing Corporation | |
dc.publisher.city | New York | |
dc.identifier.doi | 000366410700001 | |
dc.identifier.doi | 10.1155/2015/457896 | |
dc.identifier.elaba | 13966957 | |