dc.contributor.author | Tauraitė, Daiva | |
dc.contributor.author | Šiškovaitė, Greta | |
dc.contributor.author | Meškys, Rolandas | |
dc.contributor.author | Urbonavičius, Jaunius | |
dc.date.accessioned | 2023-09-18T16:47:55Z | |
dc.date.available | 2023-09-18T16:47:55Z | |
dc.date.issued | 2016 | |
dc.identifier.other | (BIS)VGT02-000033204 | |
dc.identifier.uri | https://etalpykla.vilniustech.lt/handle/123456789/116963 | |
dc.description.abstract | Modified nucleosides or nucleotides can inhibit various enzymes, and can act both as anticancer or antiviral agents. The chemical synthesis of 5-carboxyuridine esters is complicated. To overcome this, we performed a one-pot reaction using Escherichia coli thymidine phosphorylase (EC 2.4.2.4), which was active towards various 5-carboxyuracil derivatives as well as 5-fluorouracil, for the production of functionalized unnatural uridine nucleosides. Thymidine phosphorylase mediates nucleobase-exchange reaction to convert thymidine or uridine to modified nucleosides possessing a functional group at the 5th position. It was shown that the methyl, ethyl, propyl, isopropyl, butyl, cyclohexyl, cyclooctyl, and prop-2-ynyl esters of 5-carboxyuracil and 5-fluorouracil are substrates of thymidine phosphorylase, thus allowing enzymatic synthesis of modified nucleosides. This research was supported by the Research Council of Lithuania (LMT) grant [SEN-07/2015]. | eng |
dc.format.extent | p. 96 | |
dc.format.medium | tekstas / txt | |
dc.language.iso | eng | |
dc.subject | FM01 - Biokatalitinių procesų modeliavimas / Modelling of biocatalytic processes | |
dc.title | Thymidine Phosphorylase – Based Enzymatic Synthesis of Modified Nucleosides | |
dc.type | Kitos konferencijų pranešimų santraukos / Other conference presentation abstracts | |
dcterms.references | 0 | |
dc.type.pubtype | T3 - Kitos konferencijos pranešimo tezės / Other conference presentation abstracts | |
dc.contributor.institution | Vilniaus Gedimino technikos universitetas Vilniaus universitetas | |
dc.contributor.institution | Vilniaus universitetas | |
dc.contributor.faculty | Fundamentinių mokslų fakultetas / Faculty of Fundamental Sciences | |
dc.subject.researchfield | N 010 - Biologija / Biology | |
dc.subject.researchfield | T 005 - Chemijos inžinerija / Chemical engineering | |
dc.subject.researchfield | N 004 - Biochemija / Biochemistry | |
dc.subject.ltspecializations | L105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies | |
dcterms.sourcetitle | XIVth International Conference of the Lithuanian Biochemical Society, the program and abstract book | |
dc.publisher.name | Lithuanian Biochemical Society | |
dc.publisher.city | Vilnius | |
dc.identifier.elaba | 20108867 | |