dc.contributor.author | Savickienė, Jūratė | |
dc.contributor.author | Matuzevičius, Dalius | |
dc.contributor.author | Baronaitė, Sandra | |
dc.contributor.author | Treigytė, Gražina | |
dc.contributor.author | Krasovskaja, Natalija | |
dc.contributor.author | Zaikova, Ilona | |
dc.contributor.author | Navakauskas, Dalius | |
dc.contributor.author | Utkus, Algirdas | |
dc.contributor.author | Navakauskienė, Rūta | |
dc.date.accessioned | 2023-09-18T16:54:10Z | |
dc.date.available | 2023-09-18T16:54:10Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0730-2312 | |
dc.identifier.uri | https://etalpykla.vilniustech.lt/handle/123456789/117964 | |
dc.description.abstract | Human amniotic fluid (AF)-derived mesenchymal stem cells (MSCs) sharing embryonic and adult stem cells characteristics are interesting by their multipotency and the usage for regenerative medicine. However, the usefulness of these cells for revealing the fetal diseases still needs to be assessed. Here, we have analyzed the epigenetic environment in terms of histone modifications in cultures of MSCs derived from AF of normal pregnancies and those with fetal abnormalities. The comparison of MSCs samples from AF of normal pregnancies (N) and fetusaffected (P) revealed two distinct cultures by their proliferation potential (P I and P II). Cell populations from N and P I samples had similar growth characteristics and exhibited quite similar cell surface (CD44, CD90, CD105) and stemness markers (Oct4, Nanog, Sox2, Rex1) profile that was distinct in slower growing and faster senescent P II cultures. Those differences were associated with changes in 5-Cyt DNA methylation and alterations in the expression levels of chromatin modifiers (DNMT1, HDAC1/2), activating (H4ac, H3K4me3), and repressive (H3K9me2/me3, H3K27me3) histone marks. MSCs isolated from AF with the genetic or multifactorial fetal diseases (P II samples) were enriched with repressive histone marks and H4K16ac, H3K9ac, H3K14ac modifications. This study indicates that differential epigenetic environment reflects a state of AF-MSCs dependently on their growth, phenotype, and stemness characteristics suggesting a way for better understanding of epigenetic regulatory mechanisms in AF-MSCs cultures in normal and diseased gestation conditions | eng |
dc.format | PDF | |
dc.format.extent | p. 3744-3755 | |
dc.format.medium | tekstas / txt | |
dc.language.iso | eng | |
dc.relation.isreferencedby | Science Citation Index Expanded (Web of Science) | |
dc.relation.isreferencedby | Scopus | |
dc.relation.isreferencedby | BIOSIS Previews | |
dc.relation.isreferencedby | CAB Abstracts | |
dc.relation.isreferencedby | Chemical abstracts | |
dc.relation.isreferencedby | Embase | |
dc.relation.isreferencedby | MEDLINE | |
dc.source.uri | http://onlinelibrary.wiley.com/doi/10.1002/jcb.26022/pdf | |
dc.subject | IK04 - Skaitmeninės signalų apdorojimo technologijos / Digital signal processing technologies | |
dc.title | Histone modifications pattern associated with a state of mesenchymal stem cell cultures derived from amniotic fluid of normal and fetus-affected gestations | |
dc.type | Straipsnis Web of Science DB / Article in Web of Science DB | |
dcterms.references | 50 | |
dc.type.pubtype | S1 - Straipsnis Web of Science DB / Web of Science DB article | |
dc.contributor.institution | Vilniaus universitetas | |
dc.contributor.institution | Vilniaus Gedimino technikos universitetas | |
dc.contributor.faculty | Elektronikos fakultetas / Faculty of Electronics | |
dc.subject.researchfield | M 001 - Medicina / Medicine | |
dc.subject.researchfield | T 001 - Elektros ir elektronikos inžinerija / Electrical and electronic engineering | |
dc.subject.researchfield | T 007 - Informatikos inžinerija / Informatics engineering | |
dc.subject.ltspecializations | L105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies | |
dc.subject.en | amniotic fluid | |
dc.subject.en | stem cells | |
dc.subject.en | epigenetics | |
dc.subject.en | histone modifications | |
dcterms.sourcetitle | Journal of cellular biochemistry | |
dc.description.issue | Iss. 11 | |
dc.description.volume | Vol. 118 | |
dc.publisher.name | Wiley | |
dc.publisher.city | Hoboken | |
dc.identifier.doi | 000411065300022 | |
dc.identifier.doi | 10.1002/jcb.26022 | |
dc.identifier.elaba | 23256489 | |