dc.contributor.author | Naumovas, Daniel | |
dc.contributor.author | Strainienė, Eglė | |
dc.contributor.author | Sužiedėlis, Kęstutis | |
dc.date.accessioned | 2023-09-18T17:06:39Z | |
dc.date.available | 2023-09-18T17:06:39Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2538-791X | |
dc.identifier.uri | https://etalpykla.vilniustech.lt/handle/123456789/119732 | |
dc.description.abstract | Radiotherapy is a highly effective cancer treatment method. However, the increase in repopulation of tumour cells during or after treatment suggests that cell radioresistance decreases the therapeutic effect of ionizing radiation. In order to get a better understanding of a molecular response to irradiation, we used genome wide gene expression analysis to examine 31 microarray data of 6 human colorectal cancer cell lines treated with different doses of ionizing radiation from GEO depository database. In total, we identified that the expression of 13471 genes was commonly regulated in all cell lines. Furthermore, weighted gene co-expression network analysis (WGCNA) revealed 23 co-regulated modules, 5th of them are directly associated with response to ionizing radiation and possibly the acquisition of cell resistance to radiation. Thus, the identification of potential target genes might help to improve efficiency of radiotherapy. | eng |
dc.format | PDF | |
dc.format.extent | p. 49 | |
dc.format.medium | tekstas / txt | |
dc.language.iso | eng | |
dc.subject | FM01 - Biokatalitinių procesų modeliavimas / Modelling of biocatalytic processes | |
dc.title | Gene co-expression network analysis for identifying modules and functionally enriched pathways in radiation treated human colorectal cancer cell lines | |
dc.type | Konferencijos pranešimo santrauka / Conference presentation abstract | |
dcterms.references | 0 | |
dc.type.pubtype | T2 - Konferencijos pranešimo tezės / Conference presentation abstract | |
dc.contributor.institution | Vilniaus Gedimino technikos universitetas | |
dc.contributor.institution | Vilniaus Gedimino technikos universitetas Nacionalinis vėžio institutas | |
dc.contributor.institution | Nacionalinis vėžio institutas Vilniaus universitetas | |
dc.contributor.faculty | Fundamentinių mokslų fakultetas / Faculty of Fundamental Sciences | |
dc.subject.researchfield | T 005 - Chemijos inžinerija / Chemical engineering | |
dc.subject.researchfield | N 010 - Biologija / Biology | |
dc.subject.ltspecializations | L105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies | |
dc.subject.en | Genome wide gene expression analysis | |
dc.subject.en | Weighted gene co-expression network analysis (WGCNA) | |
dc.subject.en | Radioresistance | |
dc.subject.en | Human colorectal cancer | |
dcterms.sourcetitle | International conference Vita Scientia, 3rd January, 2018 Vilnius : conference book [abstract] | |
dc.publisher.name | Vita Scientia | |
dc.publisher.city | Vilnius | |
dc.identifier.elaba | 26437534 | |