dc.contributor.author | Novickij, Vitalij | |
dc.contributor.author | Švedienė, Jurgita | |
dc.contributor.author | Paškevičius, Algimantas | |
dc.contributor.author | Markovskaja, Svetlana | |
dc.contributor.author | Girkontaitė, Irutė | |
dc.contributor.author | Zinkevičienė, Auksė | |
dc.contributor.author | Lastauskienė, Eglė | |
dc.contributor.author | Novickij, Jurij | |
dc.date.accessioned | 2023-09-18T17:08:26Z | |
dc.date.available | 2023-09-18T17:08:26Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1746-0913 | |
dc.identifier.uri | https://etalpykla.vilniustech.lt/handle/123456789/120106 | |
dc.description.abstract | Aim: Determine the influence of pH on the inactivation efficiency of C. albicans in pulsed electric fields (PEF) and the evaluate the possibilities for sensitization of a drug-resistant strain to antifungal drugs. Materials & Methods: The effects of PEF (2.5 – 25 kVcm-1) with fluconazole, terbinafine and naftifine were analyzed at a pH range of 3.0–9.0. Membrane permeabilization was determined by flow cytometry and propidium iodide. Results: PEF induced higher inactivation of C. albicans at low pH and increased sensitivity to terbinafine and naftifine to which the strain was initially resistant. Up to 5 log reduction in cell survival was achieved. Conclusions: A proof of concept that electroporation can be used to sensitize drug-resistant microorganisms was presented, which is promising for treating biofilm-associated infections. | eng |
dc.format | PDF | |
dc.format.extent | p. 535-546 | |
dc.format.medium | tekstas / txt | |
dc.language.iso | eng | |
dc.relation.isreferencedby | Journal Citation Reports/Science Edition | |
dc.relation.isreferencedby | Excerpta Medica – Immunology | |
dc.relation.isreferencedby | Embase | |
dc.relation.isreferencedby | Chemical abstracts | |
dc.relation.isreferencedby | Index Medicus | |
dc.relation.isreferencedby | MEDLINE | |
dc.relation.isreferencedby | Scopus | |
dc.relation.isreferencedby | Science Citation Index Expanded (Web of Science) | |
dc.relation.isreferencedby | BIOSIS Previews | |
dc.source.uri | https://doi.org/10.2217/fmb-2017-0245 | |
dc.source.uri | https://www.futuremedicine.com/doi/10.2217/fmb-2017-0245 | |
dc.subject | MC02 - Elektros ir elektroniniai įrenginiai bei sistemos / Electrical and electronic devices and systems | |
dc.title | Pulsed electric field-assisted sensitization of multidrug-resistant Candida albicans to antifungal drugs | |
dc.type | Straipsnis Web of Science DB / Article in Web of Science DB | |
dcterms.references | 66 | |
dc.type.pubtype | S1 - Straipsnis Web of Science DB / Web of Science DB article | |
dc.contributor.institution | Vilniaus Gedimino technikos universitetas | |
dc.contributor.institution | Gamtos tyrimų centras | |
dc.contributor.institution | Gamtos tyrimų centras VŠĮ Vilniaus universiteto ligoninė Santaros klinikos | |
dc.contributor.institution | Valstybinis mokslinių tyrimų institutas Inovatyvios medicinos centras | |
dc.contributor.institution | Vilniaus universitetas | |
dc.contributor.faculty | Elektronikos fakultetas / Faculty of Electronics | |
dc.subject.researchfield | T 001 - Elektros ir elektronikos inžinerija / Electrical and electronic engineering | |
dc.subject.researchfield | N 011 - Biofizika / Biophysics | |
dc.subject.researchfield | N 010 - Biologija / Biology | |
dc.subject.ltspecializations | L105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies | |
dc.subject.en | Biofilms | |
dc.subject.en | Electroporation | |
dc.subject.en | Inactivation | |
dc.subject.en | Yeast | |
dcterms.sourcetitle | Future microbiology | |
dc.description.issue | iss. 5 | |
dc.description.volume | Vol. 13 | |
dc.publisher.name | Future Medicine Ltd | |
dc.publisher.city | London | |
dc.identifier.doi | 2-s2.0-85044760026 | |
dc.identifier.doi | 000432200300006 | |
dc.identifier.doi | 10.2217/fmb-2017-0245 | |
dc.identifier.elaba | 27053645 | |