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Pulsed electric field-assisted sensitization of multidrug-resistant Candida albicans to antifungal drugs

dc.contributor.authorNovickij, Vitalij
dc.contributor.authorŠvedienė, Jurgita
dc.contributor.authorPaškevičius, Algimantas
dc.contributor.authorMarkovskaja, Svetlana
dc.contributor.authorGirkontaitė, Irutė
dc.contributor.authorZinkevičienė, Auksė
dc.contributor.authorLastauskienė, Eglė
dc.contributor.authorNovickij, Jurij
dc.date.accessioned2023-09-18T17:08:26Z
dc.date.available2023-09-18T17:08:26Z
dc.date.issued2018
dc.identifier.issn1746-0913
dc.identifier.urihttps://etalpykla.vilniustech.lt/handle/123456789/120106
dc.description.abstractAim: Determine the influence of pH on the inactivation efficiency of C. albicans in pulsed electric fields (PEF) and the evaluate the possibilities for sensitization of a drug-resistant strain to antifungal drugs. Materials & Methods: The effects of PEF (2.5 – 25 kVcm-1) with fluconazole, terbinafine and naftifine were analyzed at a pH range of 3.0–9.0. Membrane permeabilization was determined by flow cytometry and propidium iodide. Results: PEF induced higher inactivation of C. albicans at low pH and increased sensitivity to terbinafine and naftifine to which the strain was initially resistant. Up to 5 log reduction in cell survival was achieved. Conclusions: A proof of concept that electroporation can be used to sensitize drug-resistant microorganisms was presented, which is promising for treating biofilm-associated infections.eng
dc.formatPDF
dc.format.extentp. 535-546
dc.format.mediumtekstas / txt
dc.language.isoeng
dc.relation.isreferencedbyJournal Citation Reports/Science Edition
dc.relation.isreferencedbyExcerpta Medica – Immunology
dc.relation.isreferencedbyEmbase
dc.relation.isreferencedbyChemical abstracts
dc.relation.isreferencedbyIndex Medicus
dc.relation.isreferencedbyMEDLINE
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)
dc.relation.isreferencedbyBIOSIS Previews
dc.source.urihttps://doi.org/10.2217/fmb-2017-0245
dc.source.urihttps://www.futuremedicine.com/doi/10.2217/fmb-2017-0245
dc.subjectMC02 - Elektros ir elektroniniai įrenginiai bei sistemos / Electrical and electronic devices and systems
dc.titlePulsed electric field-assisted sensitization of multidrug-resistant Candida albicans to antifungal drugs
dc.typeStraipsnis Web of Science DB / Article in Web of Science DB
dcterms.references66
dc.type.pubtypeS1 - Straipsnis Web of Science DB / Web of Science DB article
dc.contributor.institutionVilniaus Gedimino technikos universitetas
dc.contributor.institutionGamtos tyrimų centras
dc.contributor.institutionGamtos tyrimų centras VŠĮ Vilniaus universiteto ligoninė Santaros klinikos
dc.contributor.institutionValstybinis mokslinių tyrimų institutas Inovatyvios medicinos centras
dc.contributor.institutionVilniaus universitetas
dc.contributor.facultyElektronikos fakultetas / Faculty of Electronics
dc.subject.researchfieldT 001 - Elektros ir elektronikos inžinerija / Electrical and electronic engineering
dc.subject.researchfieldN 011 - Biofizika / Biophysics
dc.subject.researchfieldN 010 - Biologija / Biology
dc.subject.ltspecializationsL105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies
dc.subject.enBiofilms
dc.subject.enElectroporation
dc.subject.enInactivation
dc.subject.enYeast
dcterms.sourcetitleFuture microbiology
dc.description.issueiss. 5
dc.description.volumeVol. 13
dc.publisher.nameFuture Medicine Ltd
dc.publisher.cityLondon
dc.identifier.doi2-s2.0-85044760026
dc.identifier.doi000432200300006
dc.identifier.doi10.2217/fmb-2017-0245
dc.identifier.elaba27053645


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