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Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging

dc.contributor.authorGonos, Efstathios S.
dc.contributor.authorKapetanou, Marianna
dc.contributor.authorSereikaitė, Jolanta
dc.contributor.authorBartosz, Grzegorz
dc.contributor.authorNaparło, Katarzyna
dc.contributor.authorGrzesik, Michalina
dc.contributor.authorSadowska-Bartosz, Izabela
dc.date.accessioned2023-09-18T17:14:05Z
dc.date.available2023-09-18T17:14:05Z
dc.date.issued2018
dc.identifier.urihttps://etalpykla.vilniustech.lt/handle/123456789/121029
dc.description.abstractNon-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases.eng
dc.formatPDF
dc.format.extentp. 868-901
dc.format.mediumtekstas / txt
dc.language.isoeng
dc.relation.isreferencedbyPubMed Central
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyCurrent Contents / Clinical Medicine
dc.relation.isreferencedbyBIOSIS Previews
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)
dc.source.urihttps://doi.org/10.18632/aging.101450
dc.source.urihttps://s3-us-west-1.amazonaws.com/paperchase-aging/pdf/tfG3mPLHBMG7PDjh2.pdf
dc.subjectFM01 - Biokatalitinių procesų modeliavimas / Modelling of biocatalytic processes
dc.titleOrigin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging
dc.typeStraipsnis Web of Science DB / Article in Web of Science DB
dcterms.accessRightsThis study was performed within the project "Nanomolecular antioxidants: biological basis of targeted therapy of neurodegenerative diseases" (number 2016/22/E/NZ7/00641) financed by National Science Centre (NCN), Poland in a programme "SONATA-BIS 6". The paper is also a result of realization of research projects OPUS 9 (number 2015/17/B/NZ3/03731) financed by the NCN, Poland. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dcterms.references264
dc.type.pubtypeS1 - Straipsnis Web of Science DB / Web of Science DB article
dc.contributor.institutionInstitute of Biology, Medicinal Chemistry and Biotechnology, Athens
dc.contributor.institutionInstitute of Biology, Medicinal Chemistry and Biotechnology, Athens University of Athens
dc.contributor.institutionVilniaus Gedimino technikos universitetas
dc.contributor.institutionUniversity of Lodz
dc.contributor.institutionUniversity of Rzeszow
dc.contributor.facultyFundamentinių mokslų fakultetas / Faculty of Fundamental Sciences
dc.contributor.departmentChemijos ir bioinžinerijos katedra / Department of Chemistry and Bioengineering
dc.subject.researchfieldN 004 - Biochemija / Biochemistry
dc.subject.ltspecializationsL105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies
dc.subject.enOxidative stress
dc.subject.enCarbonylation
dc.subject.enNitration
dc.subject.enChlorination
dc.subject.enProteosome
dcterms.sourcetitleAging
dc.description.issueiss. 5
dc.description.volumevol. 10
dc.publisher.nameImpact Journals LLC
dc.publisher.cityNew York
dc.identifier.doi000433605000007
dc.identifier.doi2-s2.0-85047864129
dc.identifier.doi10.18632/aging.101450
dc.identifier.elaba29661043


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