dc.contributor.author | Novickij, Vitalij | |
dc.contributor.author | Zinkevičienė, Auksė | |
dc.contributor.author | Perminaitė, Emilija | |
dc.contributor.author | Čėsna, Robertas | |
dc.contributor.author | Lastauskienė, Eglė | |
dc.contributor.author | Paškevičius, Algimantas | |
dc.contributor.author | Švedienė, Jurgita | |
dc.contributor.author | Markovskaja, Svetlana | |
dc.contributor.author | Novickij, Jurij | |
dc.contributor.author | Girkontaitė, Irutė | |
dc.date.accessioned | 2023-09-18T17:26:17Z | |
dc.date.available | 2023-09-18T17:26:17Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | https://etalpykla.vilniustech.lt/handle/123456789/122999 | |
dc.description.abstract | Invasive infections caused by drug-resistant bacteria are frequently responsible for fatal sepsis, morbidity and mortality rates. In this work, we propose a new methodology based on nanosecond high frequency electric feld bursts, which enables successful eradication of bacteria in vivo. High frequency (15kHz) 15–25kV/cm 300–900ns pulsing bursts were used separately and in combination with acetic acid (0.1–1%) to treat Pseudomonas aeruginosa in a murine model. Acetic acid 1% alone was efective resulting in almost 10-fold reduction of bacteria viability, however combination of nanosecond electric feld and acetic acid 1% treatment was the most successful showing almost full eradication (0.01% survival compared to control) of the bacteria in the contaminated area. The short duration of the pulses (sub-microsecond) and high frequency (kHz range) of the burst enabled reduction of the muscle contractions to barely detectable level while the proposed applicators ensured predominantly topical treatment, without electroporation of deeper tissues. The results of our study have direct application for treatment of wounds and ulcers when chemical treatment is no longer efective. | eng |
dc.format | PDF | |
dc.format.extent | p. 1-9 | |
dc.format.medium | tekstas / txt | |
dc.language.iso | eng | |
dc.relation.isreferencedby | PubMed | |
dc.relation.isreferencedby | BIOSIS Previews | |
dc.relation.isreferencedby | Zoological Record | |
dc.relation.isreferencedby | Science Citation Index Expanded (Web of Science) | |
dc.relation.isreferencedby | Scopus | |
dc.rights | Laisvai prieinamas internete | |
dc.source.uri | https://doi.org/10.1038/s41598-018-32783-7 | |
dc.source.uri | https://talpykla.elaba.lt/elaba-fedora/objects/elaba:31220199/datastreams/MAIN/content | |
dc.title | Non-invasive nanosecond electroporation for biocontrol of surface infections: an in vivo study | |
dc.type | Straipsnis Web of Science DB / Article in Web of Science DB | |
dcterms.accessRights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |
dcterms.references | 57 | |
dc.type.pubtype | S1 - Straipsnis Web of Science DB / Web of Science DB article | |
dc.contributor.institution | Vilniaus Gedimino technikos universitetas | |
dc.contributor.institution | Valstybinis mokslinių tyrimų institutas Inovatyvios medicinos centras | |
dc.contributor.institution | Vilniaus universitetas | |
dc.contributor.institution | Gamtos tyrimų centras | |
dc.contributor.faculty | Elektronikos fakultetas / Faculty of Electronics | |
dc.subject.researchfield | T 001 - Elektros ir elektronikos inžinerija / Electrical and electronic engineering | |
dc.subject.researchfield | N 011 - Biofizika / Biophysics | |
dc.subject.researchfield | M 001 - Medicina / Medicine | |
dc.subject.researchfield | N 010 - Biologija / Biology | |
dc.subject.vgtuprioritizedfields | MC0404 - Bionika ir biomedicinos inžinerinės sistemos / Bionics and Biomedical Engineering Systems | |
dc.subject.ltspecializations | L105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies | |
dc.subject.en | electroporation | |
dc.subject.en | pulsed power | |
dc.subject.en | inactivation | |
dcterms.sourcetitle | Scientific reports | |
dc.description.volume | vol. 8 | |
dc.publisher.name | Nature Publishing Group | |
dc.publisher.city | London | |
dc.identifier.doi | 000445895400003 | |
dc.identifier.doi | 2-s2.0-85054072657 | |
dc.identifier.doi | 10.1038/s41598-018-32783-7 | |
dc.identifier.elaba | 31220199 | |