Decoupling theranostics with rare earth doped nanoparticles: wavelength specific functional response

Abstract

Theranostics constitutes integrated therapeutic and diagnostic functions in a single drug-probe system, promising example of which are rare-earth doped nanoparticles (RENPs). It is common to believe that theranostic multi-functionality of RENPs has to occur simultaneously; yet, on-demand control of therapy and diagnostics would make a move towards safer and more precise nanomedicines. We are exploring the possibility to optically decouple the diagnostic and therapeutic features of RENPs by using excitation wavelengths that can trigger these features individually. This paradigm shift will bring RENPs closer to routine biomedical research and clinic, as true multi-functionality can be attained.