dc.contributor.author | Javmen, Artūras | |
dc.contributor.author | Grigiškis, Saulius | |
dc.contributor.author | Rudenkov, Mark | |
dc.contributor.author | Pelišauskaitė, Eglė | |
dc.date.accessioned | 2023-09-18T20:02:32Z | |
dc.date.available | 2023-09-18T20:02:32Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1120-4826 | |
dc.identifier.other | (BIS)VGT02-000028654 | |
dc.identifier.uri | https://etalpykla.vilniustech.lt/handle/123456789/146067 | |
dc.description.abstract | Aim: β-glucan is polymeric compound in which glucose monomers are linked by β glycosidic bonds. β-glucan is produced by many different organisms – bacteria, fungi, plants. It was noted that different β-glucans can effect mammals immunity and can be human immune system modulators. Many experiments showed that β-glucans can be possibly used in bacterial disease therapy and can increase immune system cells cytotoxicity against cancer tumors. An important source of immune active β-glucan is baker’s yeast Saccharomicies cerevisiae: one of the major and structurally important component of S. cerevisiae yeast cell wall component is β-(1-3, 1-6) glucan. For baker’s yeast cultivation, YEPD medium is often used, which consists of glucose, yeast extract and peptone. The aim of this work was to use usual pabular low-cost glucose for Saccharomicies cerevisiae fermentations and optimizate cultivation process conditions for maximal β-glucan yield extraction from yeast cells. Methods: To reach this aim response surface methodology (RSM) was used. Alternate medium was also used, for cultivation of Saccharomicies cerevisiae, which consists of low-cost glucose and corn steep liquor; yeast cultivation process optimization for maximum yield of β-glucan was undertaken. Results: Optimal conditions were determined and verified for both two medium types. Conclusion: Both optimized mediums can be practical used for a β-glucan production. | eng |
dc.format.extent | p. 227-234 | |
dc.format.medium | tekstas / txt | |
dc.language.iso | eng | |
dc.relation.isreferencedby | Scopus | |
dc.relation.isreferencedby | Science Citation Index Expanded (Web of Science) | |
dc.source.uri | http://www.minervamedica.it/en/journals/minerva-biotecnologica/article.php?cod=R04Y2013N04A0227 | |
dc.subject | FM03 - Fizinių, technologinių ir ekonominių procesų matematiniai modeliai ir metodai / Mathematical models and methods of physical, technological and economic processes | |
dc.title | Saccharomicies cerevisiae yeast growth conditions optimisation using RSM methodology for the production of β-glucan | |
dc.type | Straipsnis Web of Science DB / Article in Web of Science DB | |
dc.type.pubtype | S1 - Straipsnis Web of Science DB / Web of Science DB article | |
dc.contributor.institution | JSC “Biocentras” | |
dc.contributor.institution | UAB "Biocentras" | |
dc.contributor.institution | Vilniaus Gedimino technikos universitetas | |
dc.contributor.faculty | Fundamentinių mokslų fakultetas / Faculty of Fundamental Sciences | |
dc.subject.researchfield | N 004 - Biochemija / Biochemistry | |
dc.subject.ltspecializations | L105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies | |
dcterms.sourcetitle | Minerva biotecnologica : a journal on biotechnology and molecular biology | |
dc.description.issue | no. 4 | |
dc.description.volume | Vol. 25 | |
dc.publisher.name | Edizioni Minerva Medica | |
dc.publisher.city | Turin | |
dc.identifier.elaba | 4081406 | |