dc.contributor.author | Astrauskas, Rokas | |
dc.contributor.author | Ivanauskas, Feliksas | |
dc.contributor.author | Jarockytė, Greta | |
dc.contributor.author | Karabanovas, Vitalijus | |
dc.contributor.author | Rotomskis, Ričardas | |
dc.date.accessioned | 2023-09-18T20:13:51Z | |
dc.date.available | 2023-09-18T20:13:51Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1392-5113 | |
dc.identifier.uri | https://etalpykla.vilniustech.lt/handle/123456789/147834 | |
dc.description.abstract | Three mathematical models were developed to analyze the dynamics of fluorescent dyespenetration into 3D cellular spheroids. Two fluorescent dyes were chosen to verify mathematicalmodels: rhodamine 6G (R6G) as a small molecule, which can freely penetrate through the cells,and wheat germ agglutinin (WGA) conjugated with Alexa488 fluorescent label, which reacts withthe cells plasma membrane, and its cellular penetration is significantly lower. Dye penetration andbinding to cells were modeled with nonlinear diffusion–reaction equations. System of differentialequations was solved using numerical methods, and good correspondence with physical experimentwas shown. Diffusion coefficients in extracellular matrix were determined for both fluorescent dyes,and the influence of reactions parameters to WGA penetration was analyzed. Dynamics of dyesaccumulation into cell spheroids were also determined | eng |
dc.format | PDF | |
dc.format.extent | p. 838-852 | |
dc.format.medium | tekstas / txt | |
dc.language.iso | eng | |
dc.relation.isreferencedby | Index Copernicus | |
dc.relation.isreferencedby | Science Citation Index Expanded (Web of Science) | |
dc.relation.isreferencedby | Scopus | |
dc.relation.isreferencedby | Zentralblatt MATH (zbMATH) | |
dc.relation.isreferencedby | INSPEC | |
dc.relation.isreferencedby | MathSciNet | |
dc.relation.isreferencedby | DOAJ | |
dc.relation.isreferencedby | VINITI | |
dc.rights | Laisvai prieinamas internete | |
dc.source.uri | https://www.journals.vu.lt/nonlinear-analysis/article/view/14516/13441 | |
dc.source.uri | https://doi.org/10.15388/NA.2019.5.9 | |
dc.source.uri | https://talpykla.elaba.lt/elaba-fedora/objects/elaba:41540457/datastreams/MAIN/content | |
dc.source.uri | https://talpykla.elaba.lt/elaba-fedora/objects/elaba:41540457/datastreams/COVER/content | |
dc.title | Modeling the uptake of fluorescent moleculesinto 3D cellular spheroids | |
dc.type | Straipsnis Web of Science DB / Article in Web of Science DB | |
dcterms.accessRights | This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dcterms.references | 20 | |
dc.type.pubtype | S1 - Straipsnis Web of Science DB / Web of Science DB article | |
dc.contributor.institution | Vilniaus universitetas | |
dc.contributor.institution | Nacionalinis vėžio institutas | |
dc.contributor.institution | Nacionalinis vėžio institutas Vilniaus Gedimino technikos universitetas | |
dc.contributor.institution | Nacionalinis vėžio institutas Vilniaus universitetas | |
dc.contributor.faculty | Fundamentinių mokslų fakultetas / Faculty of Fundamental Sciences | |
dc.subject.researchfield | N 011 - Biofizika / Biophysics | |
dc.subject.researchfield | T 005 - Chemijos inžinerija / Chemical engineering | |
dc.subject.vgtuprioritizedfields | FM0202 - Ląstelių ir jų biologiškai aktyvių komponentų tyrimai / Investigations on cells and their biologically active components | |
dc.subject.ltspecializations | L105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies | |
dc.subject.en | diffusion reaction equations | |
dc.subject.en | cellular spheroids | |
dc.subject.en | rhodamine 6G | |
dc.subject.en | wheat germ agglutinin | |
dc.subject.en | mathematical modeling | |
dcterms.sourcetitle | Nonlinear analysis: modelling and control | |
dc.description.issue | iss. 5 | |
dc.description.volume | vol. 24 | |
dc.publisher.name | Vilnius University Press | |
dc.publisher.city | Vilnius | |
dc.identifier.doi | 000487977600009 | |
dc.identifier.doi | 10.15388/NA.2019.5.9 | |
dc.identifier.elaba | 41540457 | |