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Biosynthesis of wyosine derivatives in tRNAPhe of Archaea: role of a remarkable bifunctional tRNAPhe:m1G/imG2 methyltransferase

dc.contributor.authorUrbonavičius, Jaunius
dc.contributor.authorMeškys, Rolandas
dc.contributor.authorGrosjean, Henri
dc.date.accessioned2023-09-18T20:28:22Z
dc.date.available2023-09-18T20:28:22Z
dc.date.issued2014
dc.identifier.issn1355-8382
dc.identifier.other(BIS)VUB02-000051874
dc.identifier.urihttps://etalpykla.vilniustech.lt/handle/123456789/150019
dc.description.abstractThe peculiar methyltransferase aTrm5a catalyzes two distinct reactions: N1-methylation of guanosine and C7-methylation of 4-demethylwyosine (imG-14) that allows the production of isowyosine (imG2), an intermediate in the 7-methylwyosine (mimG) biosynthetic pathway. This bifunctional tRNA methyltransferase that acts on two chemically distinct guanosine derivatives located at the same position of tRNAPhe is unique to certain archaea and has no homologs in eukaryotes.eng
dc.formatPDF
dc.format.extentp. 747-753
dc.format.mediumtekstas / txt
dc.language.isoeng
dc.relation.isreferencedbyEmbase
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyElsevier Biobase
dc.relation.isreferencedbyCABI Abstracts Databases
dc.relation.isreferencedbyMEDLINE
dc.relation.isreferencedbyBIOSIS Previews
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)
dc.source.urihttp://rnajournal.cshlp.org/content/20/6/747.full.pdf+html
dc.subjectFM01 - Biokatalitinių procesų modeliavimas / Modelling of biocatalytic processes
dc.titleBiosynthesis of wyosine derivatives in tRNAPhe of Archaea: role of a remarkable bifunctional tRNAPhe:m1G/imG2 methyltransferase
dc.typeStraipsnis Web of Science DB / Article in Web of Science DB
dcterms.references45
dc.type.pubtypeS1 - Straipsnis Web of Science DB / Web of Science DB article
dc.contributor.institutionVilniaus universitetas Université Paris-Sud 11, France Vilniaus Gedimino technikos universitetas
dc.contributor.institutionVilniaus universitetas
dc.contributor.institutionUniversité Paris-Sud 11, France
dc.contributor.facultyFundamentinių mokslų fakultetas / Faculty of Fundamental Sciences
dc.subject.researchfieldN 004 - Biochemija / Biochemistry
dc.subject.ltspecializationsL105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies
dc.subject.enTransfer RNA
dc.subject.enModification
dc.subject.enMethyltransferase
dc.subject.enArchaea
dc.subject.enCOG2520
dcterms.sourcetitleRNA
dc.description.issueiss. 6
dc.description.volumeVol. 20
dc.publisher.nameCold Spring Harbor Laboratory Press
dc.publisher.cityNew York
dc.identifier.doiVGT02-000028570
dc.identifier.doi000359666804415
dc.identifier.doi10.1261/rna.043315.113
dc.identifier.elaba6151347


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