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dc.contributor.authorUrbonavičius, Jaunius
dc.contributor.authorTauraitė, Daiva
dc.date.accessioned2023-09-18T20:34:40Z
dc.date.available2023-09-18T20:34:40Z
dc.date.issued2020
dc.identifier.urihttps://etalpykla.vilniustech.lt/handle/123456789/151021
dc.description.abstractTricyclic wyosine derivatives are present at position 37 in tRNAPhe of both eukaryotes and archaea. In eukaryotes, five different enzymes are needed to form a final product, wybutosine (yW). In archaea, 4-demethylwyosine (imG-14) is an intermediate for the formation of three different wyosine derivatives, yW-72, imG, and mimG. In this review, current knowledge regarding the archaeal enzymes involved in this process and their reaction mechanisms are summarized. The experiments aimed to elucidate missing steps in biosynthesis pathways leading to the formation of wyosine derivatives are suggested. In addition, the chemical synthesis pathways of archaeal wyosine nucleosides are discussed, and the scheme for the formation of yW-86 and yW-72 is proposed. Recent data demonstrating that wyosine derivatives are present in the other tRNA species than those specific for phenylalanine are discussedeng
dc.formatPDF
dc.format.extentp. 1-15
dc.format.mediumtekstas / txt
dc.language.isoeng
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyDOAJ
dc.relation.isreferencedbyChemical abstracts
dc.relation.isreferencedbyCABI - CAB Abstracts
dc.relation.isreferencedbyGenamics Journal Seek
dc.relation.isreferencedbyGlobal Health
dc.relation.isreferencedbyMEDLINE
dc.relation.isreferencedbyPubMed
dc.source.urihttps://www.mdpi.com/2218-273X/10/12/1627
dc.titleBiochemical pathways leading to the formation of wyosine derivatives in tRNA of archaea
dc.typeStraipsnis Web of Science DB / Article in Web of Science DB
dcterms.accessRightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dcterms.licenseCreative Commons – Attribution – 4.0 International
dcterms.references65
dc.type.pubtypeS1 - Straipsnis Web of Science DB / Web of Science DB article
dc.contributor.institutionVilniaus Gedimino technikos universitetas
dc.contributor.facultyFundamentinių mokslų fakultetas / Faculty of Fundamental Sciences
dc.subject.researchfieldN 004 - Biochemija / Biochemistry
dc.subject.researchfieldT 005 - Chemijos inžinerija / Chemical engineering
dc.subject.studydirectionF05 - Biotechnologijos / Biotechnology
dc.subject.vgtuprioritizedfieldsFM0202 - Ląstelių ir jų biologiškai aktyvių komponentų tyrimai / Investigations on cells and their biologically active components
dc.subject.ltspecializationsL105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies
dc.subject.enwyosine derivatives
dc.subject.entRNA modification
dc.subject.enarchaea
dc.subject.enTrm5 enzymes
dc.subject.enTaw enzymes
dcterms.sourcetitleBiomolecules
dc.description.issueiss. 12
dc.description.volumevol. 10
dc.publisher.nameMDPI
dc.publisher.cityBasel
dc.identifier.doi000601890000001
dc.identifier.doi10.3390/biom10121627
dc.identifier.elaba76572870


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