dc.contributor.author | Buivydienė, Arida | |
dc.contributor.author | Liakina, Valentina | |
dc.contributor.author | Valantinas, Jonas | |
dc.contributor.author | Norkūnienė, Jolita | |
dc.contributor.author | Mockienė, Evelina | |
dc.contributor.author | Jokubauskienė, S. | |
dc.contributor.author | Smaliukienė, R. | |
dc.contributor.author | Jančorienė, Ligita | |
dc.contributor.author | Kovalevska, L. | |
dc.contributor.author | Kashuba, E. | |
dc.date.accessioned | 2023-09-18T20:38:57Z | |
dc.date.available | 2023-09-18T20:38:57Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 2075-8251 | |
dc.identifier.other | (SCOPUS_ID)85031687061 | |
dc.identifier.uri | https://etalpykla.vilniustech.lt/handle/123456789/151594 | |
dc.description.abstract | The expression levels of the two novel oncoproteins uridine-cytidine kinase like-1 (UCKL-1) and mitochondrial ribosomal protein S18-2 (MRPS18-2) were assessed in samples of hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) using immunohistochemistry. Tissue microarray (TMA) paraffin blocks were prepared from 42 HCC tumor samples with the corresponding peri-tumor tissues and from 11 tissues of a liver with HCV-induced cirrhosis. We found that the UCKL-1 signal in the liver tissues of the peri-tumor zone in the HCC samples was stronger than that in cirrhosis (50 ± 49.44 vs. 24.27 ± 14.53; p = 0.014). The MRPS18-2 expression was weak, and there was no differences between the groups (p = 0.26). Noteworthy, the UCKL-1 protein was expressed at higher levels in peri-tumor tissues in the cases of HCC recurrence; this was confirmed for 27 older patients (63.78 ± 9.22 vs. 53.53 ± 4.07 years, p < 0.001), in parallel with enhanced UCKL-1 staining in former HCC nodules (62.69 ± 50.4 vs. 26.0 ± 30.19, p = 0.006) and microvascular invasion (p = 0.02). A multivariate analysis of prognostic factors for HCC recurrence showed that the best predictive factors for these conditions were UCKL-1 expression in tumor, vascular invasion, and HCC treatment modality, other than liver transplantation (odds ratios: 1.029, 18.143 and 11.984, R2 = 0.633, p = 0.002). In conclusion, the high UCKL-1 expression might be a prognostic factor for HCC relapse, in combination with age and microvascular invasion. MRPS18-2 protein expression has no prognostic significance in the cases of HCV-associated HCC. | eng |
dc.format | PDF | |
dc.format.extent | p. 108-114 | |
dc.format.medium | tekstas / txt | |
dc.language.iso | eng | |
dc.relation.isreferencedby | Science Citation Index Expanded (Web of Science) | |
dc.relation.isreferencedby | Scopus | |
dc.title | Expression levels of the uridine-cytidine kinase like-1 protein as a novel prognostic factor for hepatitis C virus-associated hepatocellular carcinomas | |
dc.type | Straipsnis Web of Science DB / Article in Web of Science DB | |
dcterms.references | 27 | |
dc.type.pubtype | S1 - Straipsnis Web of Science DB / Web of Science DB article | |
dc.contributor.institution | Vilniaus universitetas | |
dc.contributor.institution | Vilniaus universitetas Vilniaus Gedimino technikos universitetas | |
dc.contributor.institution | Vilniaus Gedimino technikos universitetas Vilniaus kolegija | |
dc.contributor.institution | Centre of Radiology and Nuclear Medicine Vilniaus universitetas | |
dc.contributor.institution | Forensic Medicine and Pharmacology Valstybinis patologijos centras | |
dc.contributor.institution | Valstybinis patologijos centras | |
dc.contributor.institution | Oncology and Radiobiology | |
dc.contributor.institution | Oncology and Radiobiology Karolinska Institutet | |
dc.contributor.faculty | Fundamentinių mokslų fakultetas / Faculty of Fundamental Sciences | |
dc.subject.researchfield | M 001 - Medicina / Medicine | |
dc.subject.en | hepatitis C virus (HCV) | |
dc.subject.en | Hepatocellular carcinoma (HCC) | |
dc.subject.en | MRPS18-2 | |
dc.subject.en | Prognostic factors | |
dc.subject.en | Recurrence of hepatocellular carcinoma | |
dc.subject.en | UCKL-1 | |
dcterms.sourcetitle | Acta Naturae | |
dc.description.issue | no. 3 | |
dc.description.volume | vol. 9 | |
dc.publisher.name | Russian Federation Agency for Science and Innovation | |
dc.publisher.city | Moscow | |
dc.identifier.doi | 2-s2.0-85031687061 | |
dc.identifier.doi | 85031687061 | |
dc.identifier.doi | 1 | |
dc.identifier.doi | 10.32607/20758251-2017-9-3-108-114 | |
dc.identifier.elaba | 85795157 | |