dc.contributor.author | Sūdžius, Gintaras | |
dc.contributor.author | Karalė, Diana | |
dc.contributor.author | Šiaurys, Almantas | |
dc.contributor.author | Vilienė, Rita | |
dc.contributor.author | Butrimienė, Irena | |
dc.contributor.author | Characiejus, Dainius | |
dc.contributor.author | Dumalakienė, Irena | |
dc.date.accessioned | 2023-09-18T20:39:18Z | |
dc.date.available | 2023-09-18T20:39:18Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 2314-8861 | |
dc.identifier.other | (BIS)VGT02-000030277 | |
dc.identifier.uri | https://etalpykla.vilniustech.lt/handle/123456789/151633 | |
dc.description.abstract | Purpose of this study was to evaluate the lymphocyte populations’ distribution changes in peripheral blood of patients with primary Sjogren’s syndrome (pSS). Lymphocyte populations’ distribution changes in peripheral blood of pSS patients were investigated in 52 patients with pSS and in 28 healthy controls by flow cytometry. We found decreased absolute count of CD3+ T cell population in pSS patients. Analysis of CD4+ T cell population showed significant proportion and absolute count differences in pSS patient’s blood with SSA/SSB antibodies (Abs) in comparison to controls. No significant differences were observed analyzing CD4+ and CD8+ Treg subpopulation. Proportion and absolute counts ofTh17 cells were significantly lower in pSS patient’s blood. Absolute counts of CD8+ T cells were significantly lower in pSS patients in comparison to controls and also impaired proportion and absolute counts of CD8+ subpopulations according to CD27+ and CD57+ were observed. Absolute counts of NKT and NK cells were decreased in pSS with Abs. B cells proportion was increased only in blood of pSS with Abs. Lymphocyte distribution impairment can be due to genetically determined lymphopenia or lymphocyte migration fromperiphery to inflammatory sites or/and increased susceptibility to apoptosis. | eng |
dc.format | PDF | |
dc.format.extent | p. 1-10 | |
dc.format.medium | tekstas / txt | |
dc.language.iso | eng | |
dc.relation.isreferencedby | Academic Search Complete | |
dc.relation.isreferencedby | Science Citation Index Expanded (Web of Science) | |
dc.relation.isreferencedby | Scopus | |
dc.relation.isreferencedby | Embase | |
dc.source.uri | http://dx.doi.org/10.1155/2015/854706 | |
dc.subject | FM01 - Biokatalitinių procesų modeliavimas / Modelling of biocatalytic processes | |
dc.title | Distribution of peripheral lymphocyte populations in primary Sjögren’s syndrome patients | |
dc.type | Straipsnis Web of Science DB / Article in Web of Science DB | |
dcterms.references | 40 | |
dc.type.pubtype | S1 - Straipsnis Web of Science DB / Web of Science DB article | |
dc.contributor.institution | Valstybinis mokslinių tyrimų institutas Inovatyvios medicinos centras | |
dc.contributor.institution | Valstybinis mokslinių tyrimų institutas Inovatyvios medicinos centras Vilniaus universitetas | |
dc.contributor.institution | Vilniaus Gedimino technikos universitetas Valstybinis mokslinių tyrimų institutas Inovatyvios medicinos centras | |
dc.contributor.faculty | Fundamentinių mokslų fakultetas / Faculty of Fundamental Sciences | |
dc.subject.researchfield | M 001 - Medicina / Medicine | |
dc.subject.ltspecializations | L105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies | |
dcterms.sourcetitle | Journal of immunology research | |
dc.description.volume | vol. 2015 | |
dc.publisher.name | Hindawi | |
dc.publisher.city | New York | |
dc.identifier.doi | 000354368900069 | |
dc.identifier.doi | 10.1155/2015/854706 | |
dc.identifier.elaba | 8621692 | |