Rodyti trumpą aprašą

dc.contributor.authorSauer, Natalia
dc.contributor.authorSzlasa, Wojciech
dc.contributor.authorSzewczyk, Anna
dc.contributor.authorNovickij, Vitalij
dc.contributor.authorSaczko, Jolanta
dc.contributor.authorBaczyńska, Dagmara
dc.contributor.authorDaczewska, Małgorzata
dc.contributor.authorKulbacka, Julita
dc.date.accessioned2023-12-22T07:06:33Z
dc.date.available2023-12-22T07:06:33Z
dc.date.issued2023
dc.identifier.other(crossref_id)153440979
dc.identifier.urihttps://etalpykla.vilniustech.lt/xmlui/handle/123456789/153727
dc.description.abstractCheckpoint molecules such as PD-1, LAG-3, and TIM-3 are currently under extensive investigation for their roles in the attenuation of the immune response in cancer. Various methods have been applied to overcome the challenges in this field. This study investigated the effects of nanosecond pulsed electric field (nsPEF) treatment on the expression of immune checkpoint molecules in A375 and C32 melanoma cells. The researchers found that the nsPEF treatment was able to enhance membrane permeabilization and morphological changes in the cell membrane without being cytotoxic. We found that the effects of nsPEFs on melanoma included (1) the transport of vesicles from the inside to the outside of the cells, (2) cell contraction, and (3) the migration of lipids from inside the cells to their peripheries. The treatment increased the expression of PD-1 checkpoint receptors. Furthermore, we also observed potential co-localization or clustering of MHC class II and PD-1 molecules on the cell surface and the secretion of cytokines such as TNF-α and IL-6. These findings suggest that nsPEF treatment could be a viable approach to enhance the delivery of therapeutic agents to cancer cells and to modulate the tumor microenvironment to promote an antitumor immune response. Further studies are needed to explore the mechanisms underlying these effects and their impacts on the antitumor immune response, and to investigate the potential of nsPEF treatment in combination with immune checkpoint inhibitors to improve clinical outcomes for cancer patients.eng
dc.formatPDF
dc.format.extentp. 1-18
dc.format.mediumtekstas / txt
dc.language.isoeng
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)
dc.relation.isreferencedbyScopus
dc.source.urihttps://www.mdpi.com/1424-8247/16/10/1362
dc.titleEffects of nanosecond pulsed electric field on immune checkpoint receptors in melanoma cells
dc.typeStraipsnis Web of Science DB / Article in Web of Science DB
dcterms.accessRightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
dcterms.licenseCreative Commons – Attribution – 4.0 International
dcterms.references67
dc.type.pubtypeS1 - Straipsnis Web of Science DB / Web of Science DB article
dc.contributor.institutionWroclaw Medical University
dc.contributor.institutionWroclaw Medical University University of Wroclaw
dc.contributor.institutionVilniaus Gedimino technikos universitetas Valstybinis mokslinių tyrimų institutas Inovatyvios medicinos centras
dc.contributor.institutionUniversity of Wroclaw
dc.contributor.institutionWroclaw Medical University Valstybinis mokslinių tyrimų institutas Inovatyvios medicinos centras
dc.contributor.facultyElektronikos fakultetas / Faculty of Electronics
dc.subject.researchfieldT 001 - Elektros ir elektronikos inžinerija / Electrical and electronic engineering
dc.subject.researchfieldN 010 - Biologija / Biology
dc.subject.vgtuprioritizedfieldsFM0202 - Ląstelių ir jų biologiškai aktyvių komponentų tyrimai / Investigations on cells and their biologically active components
dc.subject.ltspecializationsL105 - Sveikatos technologijos ir biotechnologijos / Health technologies and biotechnologies
dc.subject.enpulsed electric field
dc.subject.enmelanoma
dc.subject.enPD-1
dc.subject.enLAG-3
dc.subject.enTIM-3
dc.subject.encheckpoint receptors
dcterms.sourcetitlePharmaceuticals: A Commemorative Special Issue in Honor of Prof. Jolanta Saczko: Pharmaceutical Science in Electrochemotherapy
dc.description.issueiss. 10
dc.description.volumevol. 16
dc.publisher.nameMDPI
dc.publisher.cityBasel
dc.identifier.doi153440979
dc.identifier.doi2-s2.0-85175049681
dc.identifier.doi85175049681
dc.identifier.doi1
dc.identifier.doi001095456900001
dc.identifier.doi10.3390/ph16101362
dc.identifier.elaba181295894


Šio įrašo failai

FailaiDydisFormatasPeržiūra

Su šiuo įrašu susijusių failų nėra.

Šis įrašas yra šioje (-se) kolekcijoje (-ose)

Rodyti trumpą aprašą