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Toxicity of α-synuclein and Aβ40 in Saccharomyces cerevisiae

dc.contributor.authorServienė, Elena
dc.contributor.authorPilevičienė, Simona
dc.contributor.authorČasaitė, Vida
dc.date.accessioned2023-09-18T18:35:50Z
dc.date.available2023-09-18T18:35:50Z
dc.date.issued2010
dc.identifier.issn1224-5984
dc.identifier.other(BIS)VGT02-000022487
dc.identifier.urihttps://etalpykla.vilniustech.lt/handle/123456789/129717
dc.description.abstractSaccharomyces cerevisiae expression and secretion systems bearing glucose dehydrogenase gene fused with A β40 or SNCA sequences were generated and applied to study toxicity of amyloid- β and α-synuclein in yeast. Analysis of transformant growth demonstrated that cytoplasm-localized A β40 peptide exhibits higher toxicity to the yeast cells than α-synuclein. Arrangement of A β-bearing hybrid to the secretory pathway reduced the toxic effect for host cells.eng
dc.format.extentp. 5773-5780
dc.format.mediumtekstas / txt
dc.language.isoeng
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyBIOSIS Previews
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)
dc.source.urihttp://www.rombio.eu/rbl6vol15/13%20Elena_Serviene.pdf
dc.titleToxicity of α-synuclein and Aβ40 in Saccharomyces cerevisiae
dc.typeStraipsnis Web of Science DB / Article in Web of Science DB
dcterms.accessRightsIDS Number: 702PO
dcterms.references25
dc.type.pubtypeS1 - Straipsnis Web of Science DB / Web of Science DB article
dc.contributor.institutionVilniaus Gedimino technikos universitetas Gamtos tyrimų centras
dc.contributor.institutionGamtos tyrimų centras
dc.contributor.institutionBiochemijos institutas
dc.contributor.facultyFundamentinių mokslų fakultetas / Faculty of Fundamental Sciences
dc.subject.researchfieldN 010 - Biologija / Biology
dc.subject.researchfieldT 005 - Chemijos inžinerija / Chemical engineering
dc.subject.researchfieldN 004 - Biochemija / Biochemistry
dc.subject.enAmyloid-β
dc.subject.enα-synuclein
dc.subject.enGlucose dehydrogenase
dc.subject.enToxicity
dc.subject.enYeast
dcterms.sourcetitleRomanian biotechnological letters
dc.description.issueno. 6
dc.description.volumeVol. 15
dc.identifier.doiLBT02-000041341
dc.identifier.doi000285906800013
dc.identifier.elaba3936764


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