Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products
Data
2013Autorius
Aldini, G.
Vistoli, G.
Stefek, M.
Chondrogianni, N.
Grune, T.
Sereikaitė, Jolanta
Sadowska-Bartosz, I.
Bartosz, G.
Metaduomenys
Rodyti detalų aprašąSantrauka
The advanced glycoxidation end products (AGEs) and lipoxidation end products (ALEs) contribute to the development of diabetic complications and of other pathologies. The review discusses the possibilities of counteracting the formation and stimulating the degradation of these species by pharmaceuticals and natural compounds. The review discusses inhibitors of ALE and AGE formation, cross-link breakers, ALE/AGE elimination by enzymes and proteolytic systems, receptors for advanced glycation end products (RAGEs) and blockade of the ligand - RAGE axis.