Modelling the cell transmembrane potential dependence on the structure of the pulsed magnetic field coils

Abstract

During high power pulsed magnetic field treatment of biological samples the cells are subjected to both the high magnetic and induced electric fields. The extent of the influence of each treatment component is poorly studied. The work presents the finite element method analysis of pulsed inductive coils that are used for generation of pulsed magnetic and induced electric fields. The simulated coils, electrical parameters and the output characteristics are evaluated in respect to the induced cell transmembrane potential. The model of the Jurkat T lymphocyte cells is introduced in the analysis. The study includes finite element method analysis of four solenoid coils with different structure and inductance in the range of 2.8 μ H to 62 μ H. Pulsed magnetic field amplitudes up to 5 T are investigated in this work.