Programmable pulsed magnetic field system for biological applications

Abstract

In this paper, a pulsed magnetic field system developed for biological applications is presented. The proposed pulsed power setup generates repetitive controlled frequency and width square wave 0–4 kV electrical pulses and supports currents up to 1000 A. As a load, a solenoid-type inductor is used with integrated plastic cuvette for biological cells. Homogeneous repetitive microsecond range pulsed magnetic field up to 15 T inside the effective volume of the cuvette can be generated. The development process, the structure of the pulsed magnetic field setup, and the solutions implemented to achieve biomedical applicability are overviewed in this paper. The presented experimental results showing contactless permeabilization of biological cells in pulsed magnetic field have an excellent potential for the development of a new biomedical treatment technique and applicability of the setup.