Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging
Data
2018Autorius
Gonos, Efstathios S.
Kapetanou, Marianna
Sereikaitė, Jolanta
Bartosz, Grzegorz
Naparło, Katarzyna
Grzesik, Michalina
Sadowska-Bartosz, Izabela
Metaduomenys
Rodyti detalų aprašąSantrauka
Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases.